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Mitsubishi Kagaku
 
SURFHOPE SE PHARMA

SURFHOPESE PHARMA are excellent non-ionic emulsifiers marketed by Mitsubishi-Kagaku Foods Corporation.They are highly refined Sucrose Fatty Acid Esters that can be used for many pharmaceutical applications.They are generally very mild to humans and are environmentally friendly.All SURFHOPESE PHARMA Sucrose Fatty Acid Esters have US Drug Master Files.
 
Type HLB Percentage of main fatty acid Ester composition % Form
Mono ester Di,tri,poly ester
Sucrose stearate D-1803 3 Approx.70 Approx.70 Approx.80 Powder
D-1803F 3 70 20 80 Powder
D-1805 5 70 30 70 Powder
D-1807 7 70 40 60 Powder
D-1809 9 70 50 50 Powder
D-1811 11 70 55 45 Powder
D-1811F 11 70 55 45 Powder
D-1815 15 70 70 30 Powder
D-1816 16 70 75 25 Powder
Sucrose palmitate D-1615 15 80 70 30 Powder
D-1616 16 80 80 20 Powder
Sucrose laurate D-1216 16 95 80 20 Pellet
 
[Ester Composition and HLB ( Sucrose Stearate )]
  
 
[The functional properties of SURFHOPE SE PHARMA]
  
<Hydration> <Fat crystal control>
The affinity of SURFHOPE SE PHARMA for the water phase in an emulsion is derived from the hydroxyl groups (A) of the sucrose part of the molecule. Consequently SURFHOPE SE PHARMA yield emulsions which are exceptionally heat stable because the hydration of hydroxy groups is far stronger than the hydration of ether groups(B) in ethoxylated emulsifiers. SURFHOPE SE PHARMA can be used for heat stabilization and produce emulsions that are more heat stable than competing products,especially at higher temperatures.

Low HLB SURFHOPE SE PHARMA can modify the crystalline structure of solid triglycerides with useful benefits to the physical properties of the product.
     
<Oil in water emulsion> <Tablet manufacturing>
SURFHOPE SE PHARMA, with medium-high hydrophilic-lipophilic balance(HLB), tend to form liquid crystal structures in aqueous solutions.
Because of their compact structure, SURFHOPE SE PHARMA coats the interfaces of emulsions very efficiently.		 Low-medium HLB SURFHOPE SE PHARMA are not alkaline and are practically taste-free, a great advantage over magnesium stearate.
 
[Applications]
  SELECTING THE APPROPRIATE SURFHOPESE PHARMA IN PHARMACEUTICAL APPLICATIONS
  
Application Kinds of Sugar Ester Suitale Grades
O/W cream O/W=1/99-50/50
O/W=-99/1		 Mixture of Mid to High HLB SE+Low HLB SE
High HLB SE (>HLB11)		 D-1816,D-1815+D-1803 etc.
D-1816,D-1616 etc.
Solubilization O/W<5/95 High HLB SE D-1816,D-1616,D-1216 etc.
Microemulsion
Mid to High HLB SE D-1616,D-1816 etc.
Dispersions of solid particles particle size<1m
particle size<1m 		High HLB SE
High HLB SE+hydrocolloids 		D-1816 etc.
D-1816 etc.+Xanthan etc.
Improvement of fat crystallisation   Low HLB saturated SE D-1803 etc.
Tablet Lubricant
dispersibility 		Low to Mid HLB saturated SE
High HLB SE		 D-1803F stearate SE
D-1811F-D-1816 etc.
 
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